
Southeastern Indiana Vacations from $499
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Southeastern Indiana Vacation
Head off on your next big adventure with a Southeastern Indiana vacation package, and leave knowing all the details are organized. And with the ability to customize your getaway, you know it'll be one to remember. Your trip to Southeastern Indiana wouldn't be complete without getting to some of its most well-known cities, starting with Louisville. A couple of the top attractions here include KFC Yum Center and Kentucky Kingdom. Radcliff should also be on the itineraries of all Southeastern Indiana travelers. Visitors to this exciting city love Freeman Lake Park and General George Patton Museum. Whether you're planning to travel for a few days or a few weeks, Expedia are here to help you tailor-make your next dream Southeastern Indiana vacation.
The Latest Southeastern Indiana vacation packages

Hilton Cincinnati Netherland Plaza
Reviewed on May 28, 2026


Landing Apartments Near University Of Cincinnati
Reviewed on Nov 27, 2025

21c Museum Hotel Cincinnati
Reviewed on May 25, 2026

Quality Inn & Suites Florence - Cincinnati South
Reviewed on May 29, 2026
Where to stay in Southeastern Indiana

West Main Historic District
Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.
Discover the most popular places to visit in Southeastern Indiana

Louisville Slugger Museum
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

KFC Yum Center
Catch an event at KFC Yum Center during your trip to Louisville. Stroll along the riverfront or attend a sporting event in the area.

Whiskey Row
Find out about the history of Louisville when you spend time at Whiskey Row. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North
"We like this hotel because we can walk to the Derby Dinner Playhouse!"
Reviewed on May 29, 2026

Derby Hotel & Suites
"Great ex"
Reviewed on May 29, 2026

Hampton Inn New Albany Louisville West
"."
Reviewed on May 29, 2026
Find the Best Southeastern Indiana Vacation Packages
Southeastern Indiana Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | O'Hare Intl. Airport (ORD) |






















